Articles are sorted in order of publication with the most recent articles at the top.

Scleromyxoedema in a dog

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Laprais AF, Bizikova P, Lashnits EW, et al. Vet Dermatol 2017;28:503-e119. BACKGROUND: In humans, scleromyxoedema is a chronic progressive skin condition traditionally characterized by deposits of mucin, increased number of fibroblasts and fibrosis in the skin, and by systemic disease. … Read More

Serum concentration dynamic of energy homeostasis hormones, leptin, insulin, thyroid hormones, and cortisol throughout canine pregnancy and lactation

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Cardinali L, Troisi A, Verstegen JP, et al. Theriogenology 2017;97:154-158. Pregnancy and lactation represent critical periods of canine reproductive life and different hormones are required to maintain homeostasis and the correct energy requirements. The aim of this study was to … Read More

Analysis of large versus small dogs reveals three genes on the canine X chromosome associated with body weight, muscling and back fat thickness

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Plassais J, Rimbault M, Williams FJ, et al. PLoS Genet 2017;13:e1006661. Domestic dog breeds display significant diversity in both body mass and skeletal size, resulting from intensive selective pressure during the formation and maintenance of modern breeds. While previous studies … Read More

Incidental And Nonincidental Canine Thyroid Tumors Assessed By Multidetector Row Computed Tomography: A Single-Centre Cross Sectional Study In 4520 Dogs

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Bertolini G, Drigo M, Angeloni L, et al. Veterinary Radiology & Ultrasound 2017;58:304-314. Thyroid nodules are common in dogs and are increasingly likely to be detected with the increased use of advanced imaging modalities. An unsuspected, nonpalpable, asymptomatic lesion, defined … Read More

Development of the independent function of fetal thyroid glands in the dog in connection with iodothyronine concentrations in pregnant bitches, fetal fluids, and fetal serum

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Thuroczy J, Szilagyi J, Muller L, et al. Domest Anim Endocrinol 2017;58:14-18. Thyroxine (T4) and triiodothyronine (T3) concentrations in pregnant and nonpregnant bitches were measured. The allantoic and amniotic fluid samples were collected separately in the third week of pregnancy, … Read More

Free thyroxine concentrations by equilibrium dialysis and chemiluminescent immunoassays in 13 hypothyroid dogs positive for thyroglobulin antibody

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Randolph JF, Lamb SV, Cheraskin JL, et al. J Vet Intern Med 2015;29:877-881. OBJECTIVE: To determine if concentrations of free thyroxine (FT4) measured by semi-automated chemiluminescent immunoassay (CLIA) correspond to FT4 determined by equilibrium dialysis (ED) in hypothyroid dogs positive … Read More

Pharmacokinetics of Total Thyroxine after Repeated Oral Administration of Levothyroxine Solution and Its Clinical Efficacy in Hypothyroid Dogs

Van Dijl I.C., Le Traon G., Van De Meulengraaf B.D., et al.   J Vet Intern Med, 2014. 28(4): p.1229-34.   BACKGROUND: Oral levothyroxine (l-T4 ) supplementation is commonly used to treat hypothyroid dogs. OBJECTIVES: Investigate the plasma profile and … Read More

Partial Resection of the Hyoid Apparatus During Surgical Treatment of Ectopic Thyroid Carcinomas in Dogs: 5 Cases (2011–2013)

Milovancev M., Wilson D.M., Monnet E., et al.   Journal of the American Veterinary Medical Association, 2014. 244(11): p.1319-1324.   Objective-To assess perioperative findings and postoperative complications and outcomes in dogs that had ectopic thyroid carcinomas with invasion into the … Read More

Thyroid Function in 36 Dogs with Leishmaniosis Due to Leishmania Infantum before and During Treatment with Allopurinol with or without Meglumine Antimonate

Saridomichelakis M.N., Xenoulis P.G., Chatzis M.K., et al.   Vet Parasitol, 2013. 197(1-2): p.22-8.   Hypothyroidism may predispose to the development of canine leishmaniosis or it may appear during the course of the latter due to infiltration and destruction of … Read More

Ex Vivo Proton Magnetic Resonance Spectroscopy (1hmrs) Of Normal, Reactive And Malignant Canine Lymph Nodes: Evaluation Of The Choline Metabolite As A Marker For Malignancy

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Lynch KC, Odintsov BM, O’Brien RT. in Conference Proceedings. American College of Veterinary Radiology 2013;34. Introduction/Purpose: Conventional magnetic resonance imaging is widely utilized in veterinary medicine to critically evaluate soft tissue structures in disease states. Proton magnetic resonance spectroscopy CHMRS) … Read More

Use of L-thyroxine Supplementation after Radioiodine Therapy helps blunt the worsening of azotemia in Hyperthyroid cats with pre-existing Kidney Disease

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Broome MR, Peterson ME. in Conference Proceedings. American College of Veterinary Internal Medicine 2013;686. Hyperthyroidism develops in cats secondary to 1 or more autonomously functional thyroid adenomas. The progressive thy- rotoxicosis that ensues causes the chronic suppression of endoge- nous … Read More

Comparison Between Clinical, Ultrasound, Ct, Mri, And Pathology Findings In Dogs Presented For Suspected Thyroid Carcinoma

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Taeymans O, Penninck DG, Peters RM. Veterinary Radiology & Ultrasound 2013;54:61-70. This study compares clinical, ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), and pathology findings in 16 prospectively, and seven retrospectively recruited dogs presented for suspected thyroid carcinoma. Of … Read More

Paraneoplastic hypercalcemia

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Bergman PJ. Top Companion Anim Med 2012;27:156-158. Paraneoplastic syndromes (PNSs) are neoplasm-associated alterations in bodily structure or function or both that occur distant to the tumor. They are an extremely diverse group of clinical aberrations that are associated with the … Read More

Expression of thyroid-specific transcription factors in thyroid carcinoma, contralateral thyroid lobe and healthy thyroid gland in dogs

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Pessina P, Castillo V, Araujo M, et al. Research in veterinary science 2012;93:108-113. Thyrotropin receptor (TSH-R), thyroglobulin (Tg), thyroperoxidase (TPO), thyroid specific transcription factor-1 (TTF-1), paired box 8 transcription factor (PAX-8), insulin like growth factor-1 (IGF-1) and estrogen receptor alpha … Read More

Evaluation of expression and function of vascular endothelial growth factor receptor 2, platelet derived growth factor receptors-alpha and -beta, KIT, and RET in canine apocrine gland anal sac adenocarcinoma and thyroid carcinoma

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Urie BK, Russell DS, Kisseberth WC, et al. BMC Vet Res 2012;8:67. ABSTRACT: BACKGROUND: Toceranib phosphate (Palladia) has a reported objective response rate of 25% in both canine apocrine gland anal sac adenocarcinoma (AGASACA) and thyroid carcinoma (TC), with stable … Read More

Pharmacological evidence that spinal alpha(2C)- and, to a lesser extent, alpha(2A)-adrenoceptors inhibit capsaicin-induced vasodilatation in the canine external carotid circulation

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Villalon CM, Galicia-Carreon J, Gonzalez-Hernandez A, et al.  Eur J Pharmacol 2012;683:204-210. During a migraine attack capsaicin-sensitive trigeminal sensory nerves release calcitonin gene-related peptide (CGRP), producing cranial vasodilatation and central nociception; hence, trigeminal inhibition may prevent this vasodilatation and abort … Read More

Nuclear Imaging In Veterinary Endocrinology

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Daniel G. in Conference Proceedings. American College of Veterinary Internal Medicine 2012;700-702. Scintigraphic studies are used in veterinary medicine to image thyroid, parathyroid, adrenal and pancreatic diseases. By far, the most common of these studies is thyroid scintigraphy. Thyroid scintigraphy … Read More

Dietary hyperthyroidism in dogs

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Kohler B, Stengel C, Neiger R. J Small Anim Pract 2012;53:182-184. Objectives: Evaluation of dogs with elevated plasma thyroxine concentration fed raw food before and after changing the diet. Method: Between 2006 and 2011 all dogs presented with an elevated … Read More

Evaluation of Expression and Function of VEGFR2, PDGFRα, PDGFRβ, KIT, and RET in Canine Apocrine Gland of the Anal Sac Adenocarcinoma and Thyroid Carcinoma

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Urie BK. Evaluation of Expression and Function of Vegfr2, Pdgfrα, Pdgfrβ, Kit, and Ret in Canine Apocrine Gland of the Anal Sac Adenocarcinoma and Thyroid Carcinoma. Graduate Program in Comparative and Veterinary Medicine. The Ohio State University, 2012;84. Biological responses … Read More

Activation of microbubbles by short-pulsed ultrasound enhances the cytotoxic effect of cis-diamminedichloroplatinum (II) in a canine thyroid adenocarcinoma cell line in vitro

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Sasaki N, Kudo N, Nakamura K, et al. Ultrasound Med Biol 2012;38:109-118. Ultrasound targeted microbubble destruction has succeeded in delivering drugs and genes. This study was designed to explore characteristics of ultrasound targeted microbubble destruction using short-pulsed diagnostic ultrasound. Canine … Read More

Evaluation of the use of chemotherapy and other prognostic variables for surgically excised canine thyroid carcinoma with and without metastasis

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Nadeau ME, Kitchell BE. Can Vet J 2011;52:994-998. This retrospective study compared the efficacy of surgery alone versus surgery in combination with chemotherapy in the treatment of canine thyroid carcinoma; potential prognostic factors were evaluated. Forty-four dogs with biopsy-confirmed thyroid … Read More

Trilostane in dogs

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Ramsey IK. Vet Clin North Am Small Anim Pract 2010;40:269-283. Over the last 10 years, trilostane, a competitive inhibitor of steroid synthesis, is being widely used for the treatment of canine hyperadrenocorticism. Trilostane causes a significant but reversible decrease in … Read More

Insulin resistance in dogs

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Hess RS. Vet Clin North Am Small Anim Pract 2010;40:309-316. In diabetic dogs, many concurrent diseases can cause resistance to exogenous insulin. The most common concurrent disorders in diabetic dogs are hyperadrenocorticism, urinary tract infection, acute pancreatitis, neoplasia, and hypothyroidism. … Read More

Endocrine diseases in animals

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Kooistra HS, Galac S, Buijtels JJ, et al. Horm Res 2009;71 Suppl 1:144-147. BACKGROUND: Several endocrine disorders that affect humans also occur as endocrinopathies in companion animals. Spontaneous endocrine disorders in animals may provide valuable information for their counterparts in … Read More

Thyroid tumors in dogs and cats

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Barber LG. Vet Clin North Am Small Anim Pract 2007;37:755-773, vii. The clinical presentation and biologic behavior of thyroid tumors vary widely among dogs, cats, and human beings. Although thyroid tumors in dogs are rare, they are most likely to … Read More

Thyroid surgery in dogs and cats

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Radlinsky MG. Vet Clin North Am Small Anim Pract 2007;37:789-798, viii. Thyroid surgery is indicated for malignant and benign neoplasms or hyperplasia of the thyroid glands. A ventral midline cervical approach allows for bilateral thyroid exploration. Care should be taken … Read More

Canine thyroid carcinoma

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Liptak JM. Clin Tech Small Anim Pract 2007;22:75-81. Malignant thyroid carcinomas are relatively common in dogs. The majority of tumors are unilateral and nonfunctional. Before deciding on treatment options, it is important to determine whether the tumor is freely moveable … Read More

Tertiary hypothyroidism in a dog

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Shiel RE, Acke E, Puggioni A, et al.  Ir Vet J 2007;60:88-93. : A nine-year-old male entire Labrador was diagnosed with pituitary dependent hyperadrenocorticism. Following seven months of successful mitotane therapy, the dog presented with marked weight gain, seborrhoea and … Read More

Pediatric endocrinology

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Greco DS. Vet Clin North Am Small Anim Pract 2006;36:549-556, vi. Endocrine and metabolic disorders affecting puppies and kittens from birth until 6 months of age may manifest as clinical problems related to growth or to water metabolism (polydipsia and … Read More

Thyroid Storm In Cats: Fact Or Fiction

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Ward CR. in YES. American College of Veterinary Internal Medicine 2006;456-458. Thyroid storm is a syndrome described in human medicine to define a multi systemic disorder resulting from organ exposure to excessive levels of thyroid hormone.  This form of acute thyrotoxicosis … Read More

Thyroid carcinosarcoma in a dog

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Grubor B, Haynes JS Vet Pathol 2005;42:84-87. An adult male mixed breed dog developed pain, on swallowing, that lasted for 1 week. Physical exam and radiographs revealed a subcutaneous mass in the cervical area and three metastatic nodules in the … Read More

Evaluation of an in-house enzyme-linked immunosorbent assay for quantitative measurement of serum total thyroxine concentration in dogs and cats

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Lurye JC, Behrend EN, Kemppainen RJ. J Am Vet Med Assoc 2002;221:243-249. OBJECTIVE: To compare serum total thyroxine (T4) concentrations obtained with an in-house ELISA and a validated radioimmunoassay (RIA). DESIGN: Laboratory trial. SAMPLE POPULATION: 50 canine and 50 feline … Read More

Prognostic factors and patterns of treatment failure in dogs with unresectable differentiated thyroid carcinomas treated with megavoltage irradiation

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Theon AP, Marks SL, Feldman ES, et al. J Am Vet Med Assoc 2000;216:1775-1779. OBJECTIVE: To determine quality and duration of progression-free survival (PFS) time in dogs with unresectable thyroid carcinomas treated with definitive megavoltage irradiation and analyze prognostic factors … Read More

Validation of nonradioactive chemiluminescent immunoassay methods for the analysis of thyroxine and cortisol in blood samples obtained from dogs, cats, and horses

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Singh AK, Jiang Y, White T, et al. J Vet Diagn Invest 1997;9:261-268. The performances of a radioimmunoassay method, a chemiluminescent immunoassay method, and a chemiluminescent-enzyme immunoassay method were evaluated for the analysis of cortisol and total thyroxine in blood … Read More

Immunity and the endocrine system

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Greco DS, Harpold LM. Vet Clin North Am Small Anim Pract 1994;24:765-782. In conclusion, interaction between the immune and endocrine systems is highly complex. Generally, abnormalities of T suppressor cells, a result of HLA antigen genetic abnormalities, result in autoimmunity … Read More

Surgical therapy of the thyroid

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Flanders JA. Vet Clin North Am Small Anim Pract 1994;24:607-621. The surgical treatment of thyroid cancer in the cat involves excision of one or both thyroid glands while sparing at least one parathyroid gland. The most common postoperative complication of … Read More

Neurologic manifestations of thyroid disease

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Jaggy A, Oliver JE. Vet Clin North Am Small Anim Pract 1994;24:487-494. Animals with polyneuropathy associated with primary hypothyroidism have clinical neurologic signs that range from peripheral vestibular signs, lower motor neuronal deficits, laryngeal paralysis, to megaesophagus; however, a few … Read More

Selective parathyroidectomy of the dog

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Finco DR, Brown SA, Ferguson DC, et al. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 1993;57:288-292. Selective parathyroidectomy (PTX) is preferred to thyroparathyroidectomy (TPTX) when specific effects of parathyroid hormone depletion are being studied. However, because … Read More

Recognition of triiodothyronine-containing epitopes in canine thyroglobulin by circulating thyroglobulin autoantibodies

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Gaschen F, Thompson J, Beale K, et al. American journal of veterinary research 1993;54:244-247. Serum triiodothyronine autoantibody (T3 AA), triiodothyronine (T3), and thyroxine (T4) concentrations were determined in 45 canine sera containing substantial amounts of thyroglobulin autoantibodies (Tg AA); sera … Read More

Congenital hypothyroidism in a boxer dog

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Mooney CT, Anderson TJ. Journal of Small Animal Practice 1993;34:31-35. Congenital central hypothyroidism was diagnosed in a one-year-old boxer dog. The dog was presented for investigation of lameness, lethargy and obesity. Survey skeletal radiographs revealed delayed bone maturation and epiphyseal … Read More

Prevalence of autoantibodies to thyroglobulin, thyroxine, or triiodothyronine and relationship of autoantibodies and serum concentrations of iodothyronines in dogs

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Thacker EL, Refsal KR, Bull RW. American journal of veterinary research 1992;53:449-453. Assays were developed to detect and measure autoantibodies (AA) to thyroglobulin (Tg) and to the thyroid hormones, thyroxine (T4) and triiodothyronine (T3). An ELISA to detect AA to … Read More

Immunocytochemistry of canine thyroid tumors

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Leblanc B, Parodi AL, Lagadic M, et al. Vet Pathol 1991;28:370-380. Immunocytochemical studies using the peroxidase-antiperoxidase method with commercial antibodies against thyroglobulin, calcitonin, calcitonin gene-related peptide (CGRP), neuron specific enolase (NSE), somatostatin, and neurotensin were performed on 38 Bouin-fixed, paraffin-embedded … Read More

Thyroid tumours in the dog

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Sullivan M, Cox F, Pead MJ, et al. Journal of Small Animal Practice 1987;28:505-512. The clinical, radiological and histopathological features of 30 thyroid tumours in the dog are described. Ten tumours were considered suitable for surgical removal and in a … Read More

Carcinoma of Ectopic Thyroid in a Dog

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Walsh KM, Diters RW. Journal of American Animal Hospital Association 1984;20:665-668. The differential diagnoses for heart base mass include aortic body chemodectoma, ectopic thyroid tumor, ectopic parathyroid tumor, mesothelioma, cardiac myxoma, and lymphadenopathy. The inci- dence of ectopic thyroid neoplasms … Read More

Circulating antitriiodothyronine autoantibodies in two euthyroid patients: apparent lack of interference in total T3 radioimmunoassay based on second antibody or solid phase separation techniques

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Beck-Peccoz P, Romelli PB, Faglia G. J Endocrinol Invest 1983;6:333-340. Two clinically euthyroid patients were noted to have low total T3 levels as assessed by RIA using either dextran-charcoal (DC) or polyethylene glycol (PEG) for separation of bound from unbound … Read More

Unilateral thyroid neoplasm in a cat

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O’Brien SE, Riley JH, Hagemoser WA. Vet Rec 1980;107:199-200. An aged cat with a thyroid neoplasm showed clinical signs and had laboratory data and post mortem findings similar to those observed in human and canine patients afflicted with hyperthyroidism. Because … Read More

The thyroid gland–a review

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Mason R, Wilkinson JS. Aust Vet J 1973;49:44-49. Diseases of the thyroid have been known for many thousands of years, having been recorded by the Ancient Chinese, and epidemic goitre still affects an estimated 200 million people. Most of the notorious … Read More